2019年科研成果

发布者:行政办公室(A)发布时间:2019-12-31浏览次数:7233

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116.  Common Activation Mechanism of Class A GPCRs.

Zhou Q #, Yang D #, Wu M, Guo Y, Guo W, Zhong L, Cai X, Dai A, Jang W, Shakhnovich E I, Liu Z J, Stevens R C, Lambert N A, Babu M M, Wang M W, Zhao SW. Elife. 2019 Dec 19;8:e50279.  doi: 10.7554/eLife.50279.

 

115. Switching From Fear to No Fear by Different Neural Ensembles in Mouse Retrosplenial Cortex.

Wang G, Xie H, Wang L, Luo W, Wang Y, Jiang J, Xiao C, Xing F, Guan J S.  Cereb Cortex. 2019 Dec 17;29(12):5085-5097.  doi: 10.1093/cercor/bhz050.

 

114. Increasing the Targeting Scope and Efficiency of Base Editing With Proxy-BE Strategy.

Liu Y, Li G, Yang G, Gu H, Huang S, Yu W, Qin G, Liu X, Zhou F, Huang XX, Wei Y. FEBS Lett. 2019 Dec 14. doi: 10.1002/1873-3468.13719. Online ahead of print.

 

113.  One Prime for All Editing.

Yang L, Yang B, Chen J.  Cell. 2019 Dec 12;179(7):1448-1450. doi: 10.1016/j.cell.2019.11.030.

 

112. Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α 2C Adrenergic Receptor.

Chen X, Xu Y, Qu L, Wu L, Han G W, Guo Y, Wu Y, Zhou Q, Sun Q, Chu C, Yang J, Yang L, Wang Q, Yuan S, Wang L, Hu T, Tao H, Sun Y, Song Y, Hu L, Liu Z J, Stevens R C, Zhao SW, Wu D, Zhong GS. Cell Rep. 2019 Dec 3;29(10):2936-2943.e4.  doi: 10.1016/j.celrep.2019.10.112.

 

111.  Structural Basis of the Diversity of Adrenergic Receptors.

Qu L, Zhou Q, Xu Y, Guo Y, Chen X, Yao D, Han GW, Liu ZJ, Stevens RC, Zhong GS, Wu D, Zhao S.

Cell Rep. 2019 Dec 3;29(10):2929-2935.e4. doi: 10.1016/j.celrep.2019.10.088.

 

110. Intra-Seminiferous Tubular Injection of Vascular Endothelial Growth Factor C Sustained-Release Ultrafine Particles: A Novel Method for Improving the Regeneration of Spermatogenesis After Chemotherapy.

Zhao L, Yao C, Zhu Z, Liu N, Zhai J, Wang Y, Yang C, Tian R, Li P, Chen H, Wan Z, Zhi E, Huang Y, Zhou Z, Li Z. J Biomed Nanotechnol. 2019 Dec 1;15(12):2376-2392. doi: 10.1166/jbn.2019.2857.

 

109.     Intra-articular Injection of Magnesium Chloride Attenuates Osteoarthritis Progression in Rats.

Yao H, Xu J K, Zheng N Y, Wang J L, Mok S W, Lee Y W, Shi L, Wang J Y, Yue J, Yung S H, Hu P J, Ruan Y C, Zhang Y F, Ho K W, Qin L. Osteoarthritis Cartilage. 2019 Dec;27(12):1811-1821.  doi: 10.1016/j.joca.2019.08.007. Epub 2019 Sep 16.

 

108.  Effects of reprogramming on genomic imprinting and the application of pluripotent stem cells.

Li X, Li MJ, Yang Y, Bai Y. Stem Cell Res. 2019 Dec;41:101655. doi: 10.1016/j.scr.2019.101655. Epub 2019 Nov 9.


107.  Surface Engineering of Biodegradable Magnesium Alloys for Enhanced Orthopedic Implants.

Li Y, Zhao S, Li S, Ge Y, Wang R, Zheng L, Xu J, Sun M, Jiang Q, Zhang YF, Wei H. Small. 2019 Dec;15(51):e1904486. doi: 10.1002/smll.201904486. Epub 2019 Nov 22.

 

106.  ER-localized Hrd1 Ubiquitinates and Inactivates Usp15 to Promote TLR4-induced Inflammation During Bacterial Infection.

Lu Y, Qiu Y, Chen P, Chang H, Guo L, Zhang F, Ma L, Zhang C, Zheng X, Xiao J, Zhong R, Han L, Xu X, Zhang Y, Li D, Zhong GS, Boyton R, Huang Y, He Y, Hu R, Wei B, Wang H. Nat Microbiol. 2019 Dec;4(12):2331-2346.  doi: 10.1038/s41564-019-0542-2.


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105.  Protein Tyrosine Phosphatase Receptor Type R (PTPRR) Antagonizes the Wnt Signaling Pathway in Ovarian Cancer by Dephosphorylating and Inactivating β-Catenin.

Wang Y, Cao J, Liu W, Zhang J, Wang Z, Zhang Y, Hou L, Chen S, Hao P, Zhang LY, Zhuang M, Yu Y, Li D, Fan GF. J Biol Chem. 2019 Nov 29;294(48):18306-18323.  doi: 10.1074/jbc.RA119.010348. Epub 2019 Oct 25.

 

104.  Elucidating the Active δ-Opioid Receptor Crystal Structure With Peptide and Small-Molecule Agonists.

Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han G W, Holleran B J, Van der Poorten O, White K L, Hanson M A, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu Z J, Muller C E, Stevens R CSci Adv. 2019 Nov 27;5(11):eaax9115.  doi: 10.1126/sciadv.aax9115.  eCollection 2019 Nov.

 

103.  Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction.

Wang S, He Z, Wang X, Li H, Liu XS. Elife. 2019 Nov 26;8:e49020. doi: 10.7554/eLife.49020.

 

102.    Drosophila CTP Synthase Can Form Distinct Substrate- And Product-Bound Filaments.

Zhou X, Guo C J, Hu H H, Zhong J, Sun Q, Liu D, Zhou S, Chang C C, Liu J L. J Genet Genomics. 2019 Nov 20;46(11):537-545. doi: 10.1016/j.jgg.2019.11.006. Epub 2019 Nov 29.

 

101.  Site-directed RNA Editing (SDRE): Off-target Effects and Their Countermeasures.

Shaoshuai Mao, Yajing Liu , Shisheng Huang , Xingxu Huang , Tian Chi.

Mao S, Liu Y, Huang S, Huang XX, Chi T. J Genet Genomics. 2019 Nov 20;46(11):531-535.  doi: 10.1016/j.jgg.2019.11.005. Epub 2019 Nov 27.

 

100. YTHDF2 Reduction Fuels Inflammation and Vascular Abnormalization in Hepatocellular Carcinoma.

Hou J, Zhang H, Liu J, Zhao Z, Wang J, Lu Z, Hu B, Zhou J, Zhao Z, Feng M, Zhang H, Shen B, Huang X, Sun B, He C, Xia Q. Mol Cancer. 2019 Nov 18;18(1):163.  doi: 10.1186/s12943-019-1082-3.

 

99.   Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor.

Zhou F, Ding K, Zhou Y, Liu Y, Liu X, Zhao F, Wu Y, Zhang X, Tan Q, Xu F, Tan W, Xiao Y, Zhao S, Tao HJ Med Chem. 2019 Nov 14;62(21):9983-9989.  doi: 10.1021/acs.jmedchem.9b00283. Epub 2019 Oct 17.

 

98.    The post-PAM Interaction of RNA-guided spCas9 With DNA Dictates Its Target Binding and Dissociation.

Zhang Q, Wen F, Zhang S, Jin J, Bi L, Lu Y, Li M, Xi X G, Huang X, Shen B, Sun B. Sci Adv. 2019 Nov 13;5(11):eaaw9807.  doi: 10.1126/sciadv.aaw9807.  eCollection 2019 Nov.


97.   The predictive power of tumor mutational burden in lung cancer immunotherapy response is influenced by patients' sex.

Wang S, Zhang J, He Z, Wu K, Liu XS.Int J Cancer. 2019 Nov 15;145(10):2840-2849. doi: 10.1002/ijc.32327. Epub 2019 Apr 29.


96.   Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist.

Laprairie RB, Vemuri K, Stahl EL, Korde A, Ho JH, Grim TW, Hua T, Wu Y, Stevens RC, Liu ZJ, Makriyannis A, Bohn LM. Mol Pharmacol. 2019 Nov;96(5):619-628. doi: 10.1124/mol.119.116483. Epub 2019 Sep 12.


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95.  Stress-Induced Metabolic Disorder in Peripheral CD4 + T Cells Leads to Anxiety-like Behavior.

Fan K Q, Li Y Y, Wang H L, Mao X T, Guo J X, Wang F, Huang L J, Li Y N, Ma X Y, Gao Z J, Chen W, Qian D D, Xue W J, Cao Q, Zhang L, Shen L, Zhang L, Tong C, Zhong J Y, Lu W, Lu L, Ren K M, Zhong GS, Wang Y, Tang M, Feng X H, Chai R J, Jin J.  Cell. 2019 Oct 31;179(4):864-879.e19.  doi: 10.1016/j.cell.2019.10.001.

 

94.   Quantitative Phosphoproteomics Reveals System-Wide Phosphorylation Network Altered by Spry in Mouse Mammary Stromal Fibroblasts.

Shi T, Yao L, Han Y, Hao PL,Lu PF. Int J Mol Sci. 2019 Oct 30;20(21):5400.  doi: 10.3390/ijms20215400.

 

93.  Comparison of Cytosine Base Editors and Development of the BEable-GPS Database for Targeting Pathogenic SNVs.

Wang Y, Gao R, Wu J, Xiong Y C, Wei J, Zhang S, Yang B, Chen J, Yang L. Genome Biol. 2019 Oct 23;20(1):218.  doi: 10.1186/s13059-019-1839-4.

 

92.   The TOR Pathway Modulates Cytoophidium Formation in Schizosaccharomyces pombe.

Andreadis C, Hulme L, Wensley K, Liu J L.  J Biol Chem. 2019 Oct 4;294(40):14686-14703.  doi: 10.1074/jbc.RA119.009913.  Epub 2019 Aug 19.


91.   IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.

Yan C, Liu J, Gao J, Sun Y, Zhang L, Song H, Xue L, Zhan L, Gao GJ, Ke Z, Liu Y, Liu JN. Cell Death Dis. 2019 Oct 22;10(11):800. doi: 10.1038/s41419-019-2039-6.

 

90.   Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells.

Yu J, Liu Z, Liang Y, Luo F, Zhang J, Tian C, Motzik A, Zheng M, Kang J, Zhong G, Liu C, Fang P, Guo M, Razin E, Wang J. Nat Commun. 2019 Oct 11;10(1):4664. doi: 10.1038/s41467-019-12710-8.


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89.   Ras Downstream Effector GGCT Alleviates Oncogenic Stress.

He Z, Wang S, Shao Y, Zhang J, Wu X, Chen Y, Hu J, Zhang F, Liu X S. iScience. 2019 Sep 27;19:256-266.  doi: 10.1016/j.isci.2019.07.036.  Epub 2019 Jul 26.

 

88.   LncRNA- Safe Contributes to Cardiac Fibrosis Through Safe- Sfrp2-HuR Complex in Mouse Myocardial Infarction.

Hao K, Lei W, Wu H, Wu J, Yang Z, Yan S, Lu X A, Li J, Xia X, Han X, Deng W, Zhong G, Zhao Z A, Hu S. Theranostics. 2019 Sep 25;9(24):7282-7297.  doi: 10.7150/thno.33920.  eCollection 2019.

 

87.   Temperature-sensitive Cytoophidium Assembly in Schizosaccharomyces Pombe.

Zhang J, Liu J L.  J Genet Genomics. 2019 Sep 20;46(9):423-432.  doi: 10.1016/j.jgg.2019.09.002.  Epub 2019 Sep 24.

 

86.   Construction and Optimization of a Base Editor Based on the MS2 System.

Zhang S, Feng S, Jiang W, Huang XX , Chen J. Animal Model Exp Med. 2019 Sep 5;2(3):185-190.  doi: 10.1002/ame2.12080.  eCollection 2019 Sep.


85.   Crystal structure of a bacterial homolog to human lysosomal transporter, spinster.

Zhou F, Yao DQ ,Rao B,Zhang L, Nie W , Zou Y , Zhao J ,Cao Y . SCIENCE BULLETIN. 2019 Sep 30; 64(18):1310-1317.


84.  A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection.

Cui C, Wang Y, Liu JN, Zhao J, Sun P, Wang S. Nat Commun. 2019 Sep 20;10(1):4298.


83.  Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.

Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Synder NW, Horng T.  Nat Immunol. 2019 Sep;20(9):1186-1195.


82.   Efficient Generation of Pathogenic A-to-G Mutations in Human Tripronuclear Embryos via ABE-Mediated Base Editing.

Li G, Liu X, Huang S, Zeng Y, Yang G, Lu Z, Zhang Y, Ma X, Wang L, Huang XX, Liu J. Mol Ther Nucleic Acids. 2019 Sep 6;17:289-296. doi: 10.1016/j.omtn.2019.05.021. Epub 2019 Jun 5.

 

81.   Improving Editing Efficiency for the Sequences with NGH PAM Using xCas9-Derived Base Editors.

Liu X, Li G, Zhou X, Qiao Y, Wang R, Tang S, Liu J, Wang L, Huang XX. Mol Ther Nucleic Acids. 2019 Sep 6;17:626-635. doi: 10.1016/j.omtn.2019.06.024. Epub 2019 Jul 12.

 

80.   Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins.

Xue D, Xu T, Wang H, Wu M, Yuan Y, Wang W, Tan Q, Zhao F, Zhou F, Hu T, Jiang Z, Liu ZJ, Zhao S, Liu D, Wüthrich K, Tao H. Chemistry. 2019 Sep 6;25(50):11635-11640. doi: 10.1002/chem.201903190. Epub 2019 Aug 13.

 

79.   XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.

Hou S, Qu D, Li Y, Zhu B, Liang D, Wei X, Tang W, Zhang Q, Hao J, Guo W, Wang W, Zhao S, Wang Q, Azam S, Khan M, Zhao H, Zhang LY, Lei H. Nucleic Acids Res. 2019 Sep 5;47(15):8239-8254. doi: 10.1093/nar/gkz532.

 

78.   Sex Differences in Cancer Immunotherapy Efficacy, Biomarkers, and Therapeutic Strategy.

Wang S, Cowley LA, Liu XS. Molecules. 2019 Sep 4;24(18). pii: E3214. doi: 10.3390/molecules24183214.

 

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77.   Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum.

Peng J, Sheng AL, Xiao Q, Shen L, Ju XC, Zhang M, He ST, Wu C, Luo ZG. J Mol Cell Biol. 2019 Aug 19;11(8):636-648. doi: 10.1093/jmcb/mjy089.


76.   AAV-ie enables safe and efficient gene transfer to inner ear cells.

Tan F, Chu C, Qi J, Li W, You D, Li K, Chen X, Zhao W, Cheng C, Liu X, Qiao Y, Su B, He S, Zhong C, Li H, Chai R, Zhong G. Nat Commun. 2019 Aug 19;10(1):3733.

 

75.   Ca2+-regulated Ca2+ channels with an RCK gating ring control plant symbiotic associations.

Kim S, Zeng W, Bernard S, Liao J, Venkateshwaran M, Ane JM, Jiang Y. Nat Commun. 2019 Aug 16;10(1):3703.


74.  Purification, characterization, and application of a high activity 3-ketosteroid-Delta(1)-dehydrogenase from Mycobacterium neoaurum DSM 1381.

Zhang R, Xu X, Cao H, Yuan C, Yuminaga Y, Zhao S, Shi J, Zhang B.  Appl Microbiol Biotechnol. 2019 Aug;103(16):6605-6616.


73.   Mutual inhibitions between epidermal growth factor receptor signaling and miR-124a control pancreatic progenitor proliferation.

Zhang ZW, Zhai W, Liang J, Chen Z, Ma M, Zhao Y, Liang Y, Li X, Teng CB. J Cell Physiol. 2019 Aug;234(8):12978-12988. doi: 10.1002/jcp.27967. Epub 2018 Dec 7.

  

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72.   MOV10L1 Binds RNA G-Quadruplex in a Structure-Specific Manner and Resolves It More Efficiently Than MOV10.

Zhang X, Yu L, Ye S, Xie J, Huang XX, Zheng K, Sun B. iScience. 2019 Jul 26;17:36-48.  doi: 10.1016/j.isci.2019.06.016.  Epub 2019 Jun 15.


71.   Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins.

Xue D, Xu T, Wang H, Wu M, Yuan Y, Wang W, Tan Q, Zhao F, Zhou F, Hu T, Jiang Z, Liu ZJ, Zhao S, Liu D, Wüthrich K, Tao H. Chemistry. 2019 Jul 31. 


70.    Roles of MicroRNAs in Establishing and Modulating Stem Cell Potential.

Zhang Z, Zhuang L, Lin CP.  Int J Mol Sci. 2019 Jul 25;20(15). pii: E3643.  


69.   Mammary stem cells, where art thou?

Lu P, Zhou T, Xu C, Lu Y. Wiley Interdiscip Rev Dev Biol. 2019 Jul 19:e357.

 

68.   Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase.

Jiang SY, Tang JJ, Xiao X, Qi W, Wu S, Jiang C, Hong J, Xu J, Song BL, Luo J. PLoS Genet. 2019 Jul 19;15(7):e1008289. doi: 10.1371/journal.pgen.1008289. eCollection 2019 Jul.

 

67.   In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions.

Yu L#, He W#, Xie J#, Guo R#, Ni J, Zhang X, Xu Q, Wang C, Yue Q, Li F, Luo M, Sun B, Ye L, Zheng K. J Vis Exp. 2019 Jul 17;(149). doi: 10.3791/59830.


66.   Traffic jam regulates the function of the ovarian germline stem cell progeny differentiation niche during pre-adult stage in Drosophila.

Li M, Hu X, Zhang S, Ho MS, Wu G, Zhang L. Sci Rep. 2019 Jul 12;9(1):10124.


65.  Self-capping of nucleoprotein filaments protects the Newcastle disease virus genome.

Song X, Shan H, Zhu Y, Hu S, Xue L, Chen Y, Ding W, Niu T, Gu J, Ouyang S, Shen QT, Liu ZJ.Elife. 2019 Jul 10;8. pii: e45057. 


64.   Base pair editing in goat: nonsense codon introgression into FGF5 results in longer hair.

Li G, Zhou S, Li C, Cai B, Yu H, Ma B, Huang Y, Ding Y, Liu Y, Ding Q, He C, Zhou J, Wang Y, Zhou G, Li Y, Yan Y, Hua J, Petersen B, Jiang Y, Sonstegard T, Huang XX, Chen Y, Wang X. FEBS J. 2019 Jul 5.


63.   Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor.

Lu Y, Qin S, Zhang B, Dai A, Cai X, Ma M, Gao ZG, Yang D, Stevens RC, Jacobson KA, Wang MW, Shui W. Anal Chem. 2019 Jul 2;91(13):8162-8169.


62.   Functionality-Independent DNA Encoding of Complex Natural Products.

Ma P, Xu H, Li J, Lu F, Ma F, Wang S, Xiong H, Wang W, Buratto D, Zonta F, Wang N, Liu K, Hua T, Liu ZJ, Yang G, Lerner RA. Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9254-9261.

 

61.   Citrate-assisted efficient local delivery of naked oligonucleotide into live mouse brain cells.

Zhou H, Zhang S, Lv F, Sun W, Wang L, Fan C, Li J, Hu J.Cell Prolif. 2019 Jul;52(4):e12622.

 

60. APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 phase in Multicellular Systems.

Kimata Y. Trends Cell Biol. 2019 Jul;29(7):591-603.


59.   Sulindac-derived retinoid X receptor-α modulator attenuates atherosclerotic plaque progression and destabilization in ApoE-/- mice.

Shen L, Sun Z, Nie P, Yuan R, Cai Z, Wu C, Hu L, Jin S, Zhou H, Zhang X, He B. Br J Pharmacol. 2019 Jul;176(14):2559-2572. doi: 10.1111/bph.14682. Epub 2019 May 23.


58.   Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells.

Gambarotto D, Pennetier C, Ryniawec JM, Buster DW, Gogendeau D, Goupil A, Nano M, Simon A, Blanc D, Racine V, Kimata Y, Rogers GC, Basto R. Dev Cell. 2019 Jul 1;50(1):11-24.e10. doi: 10.1016/j.devcel.2019.04.036. Epub 2019 May 23.


6月

57.  The structure-based traceless specific fluorescence labeling of the smoothened receptor

Xue D , Ye L , Zheng J , Wu Y , Zhang X , Xu Y , Li T , Stevens RC ,Xu F , Zhuang M , Zhao S , Zhao F , Tao H . Org Biomol Chem. 2019 Jun 26;17(25):6136-6142.


56.   CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists.

Liu F, Jiang W, Sui Y, Meng W, Hou L, Li T, Li M, Zhang LY, Mo J, Wang J, Zhao Y, Zhang L, Ma J, Tang Y. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12986-12995. doi: 10.1073/pnas.1815780116. Epub 2019 Jun 10.


55. Forming cytoophidia prolongs the half-life of CTP synthase.

Sun Z, Liu JLCell Discov. 2019 Jun 18;5:32.

  

54. Overexpression of MicroRNA-10a in Germ Cells Causes Male Infertility by Targeting Rad51 in Mouse and Human.

Gao H, Wen H, Cao C, Dong D, Yang C, Xie S, Zhang J, Huang X, Huang XX, Yuan S, Dong W. Front Physiol. 2019 Jun 18;10:765.

  

53. In situ structure and assembly of the multidrug efflux pump AcrAB-TolC.

Shi X, Chen M, Yu Z, Bell JM, Wang H, Forrester I, Villarreal H, Jakana J, Du DJ, Luisi BF, Ludtke SJ, Wang Z. Nat Commun. 2019 Jun 14;10(1):2635.

  

52. Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis.

Yan Y, Qin D, Hu B, Zhang C, Liu S, Wu D, Huang W, Huang XX, Wang L, Chen X, Zhang L. Mol Ther Nucleic Acids. 2019 Jun 7;16:494-504.

  

51. Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons.

Zhang S, Lv F, Yuan Y, Fan C, Li J, Sun W, Hu J. Front Neurosci. 2019 Jun 4;13:565.

  

50. A subcortical excitatory circuit for sensory-triggered predatory hunting in mice.

Shang C, Liu A, Li D, Xie Z, Chen Z, Huang M, Li Y, Wang Y, Shen WL, Cao P. Nat Neurosci. 2019 Jun;22(6):909-920.

  

49. Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting.

Zhao ZD, Chen Z, Xiang X, Hu M, Xie H, Jia X, Cai F, Cui Y, Chen Z, Qian L, Liu J, Shang C, Yang Y, Ni X, Sun W, Hu J, Cao P, Li H, Shen WL. Nat Neurosci. 2019 Jun;22(6):921-932.

  

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48. Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes.

Huang X, Feng T, Jiang Z, Meng J, Kou S, Lu Z, Chen W, Lin CP, Zhou B, Zhang H. J Biol Chem. 2019 May 31;294(22):8894-8906.

  

47. Developing ABEmax-NG with Precise Targeting and Expanded Editing Scope to Model Pathogenic Splice Site Mutations In Vivo.

Huang S, Liao Z, Li X, Liu Z, Li G, Li J, Lu Z, Zhang Y, Li XJ, Ma X, Sun Q, Huang XX. iScience. 2019 May 31;15:640-648.


46. Molecular Mechanism of Acetate Transport through the Acetate Channel SatP.

Wu M, Sun L, Zhou Q, Peng Y, Liu ZJ, Zhao SW.  J Chem Inf Model. 2019 May 28;59(5):2374-2382. 

  

45. A piggyBac-based TANGO GFP assay for high throughput screening of GPCR ligands in live cells.

Li F, Jiang X, Luo LL, Xu YM, Huang XX, Huang C, Zhang Y. Cell Commun Signal. 2019 May 23;17(1):49.

  

44. Cell cycle- and genomic distance-dependent dynamics of a discrete chromosomal region.

Ma HH, Tu LC, Chung YC, Naseri A, Grunwald D, Zhang S, Pederson T. J Cell Biol. 2019 May 6;218(5):1467-1477.

  

43. Central Processing of Itch in the Midbrain Reward Center.

Su XY, Chen M, Yuan Y, Li Y, Guo SS, Luo HQ, Huang C, Sun W, Li Y, Zhu MX, Liu MG, Hu J, Xu TL. Neuron. 2019 May 22;102(4):858-872.e5.

  

42. CCN1-Induced Cellular Senescence Promotes Heart Regeneration.

Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau LF, Zhou B, Zhang H. Circulation. 2019 May 21;139(21):2495-2498.

  

41. Model-based understanding of single-cell CRISPR screening.

Duan B, Zhou C, Zhu C, Yu Y, Li G, Zhang S, Zhang C, Ye X, Ma HH, Qu S, Zhang Z, Wang P, Sun S, Liu Q. Nat Commun. 2019 May 20;10(1):2233.

  

40. Wingless modulates activator protein-1-mediated tumor invasion.

Zhang SP, Guo X, Wu H, Sun Y, Ma X, Li J, Xu Q, Wu C, Li Q, Jiang C, Li W, Ho MS, Lv Z, Xue L. Oncogene. 2019 May;38(20):3871-3885.

  

39. Discrimination of the hierarchical structure of cortical layers in 2-photon microscopy data by combined unsupervised and supervised machine learning.

Li D, Zavaglia M, Wang G, Xie H, Hu Y, Werner R, Guan JS, Hilgetag CC. Sci Rep. 2019 May 15;9(1):7424.


38. Efficient ligand discovery from natural herbs by integrating virtual screening, affinity mass spectrometry and targeted metabolomics.

Wang Z, Liang H, Cao H, Zhang B, Li J, Wang W, Qin S, Wang Y, Xuan L, Lai L, Shui WQ. Analyst. 2019 May 7;144(9):2881-2890. 


37. Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.

Gui X, Luo F, Li Y, Zhou H, Qin Z, Liu Z, Gu J, Xie M, Zhao K, Dai B, Shin WS, He J, He L, Jiang L, Zhao M, Sun B, Li X, Liu C, Li D. Nat Commun. 2019 May 1;10(1):2006.

  

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36. Rescuing Replication from Barriers: Mechanistic Insights from Single-Molecule Studies.

Sun B. Mol Cell Biol. 2019 Apr 30;39(10). pii: e00576-18.

  

35. Nucleofection with Plasmid DNA for CRISPR/Cas9-Mediated Inactivation of Programmed Cell Death Protein 1 in CD133-Specific CAR T Cells.

Hu B, Zou Y, Zhang L, Tang J, Niedermann G, Firat E, Huang XX, Zhu X. Hum Gene Ther. 2019 Apr;30(4):446-458.  

  

34. Vitamin K2-Dependent GGCX and MGP Are Required for Homeostatic Calcium Regulation of Sperm Maturation.

Ma H, Zhang BL, Liu BY, Shi S, Gao DY, Zhang TC, Shi HJ, Li Z, Shum WW. iScience. 2019 Apr 26;14:210-225.


33. Critical role of spectrin in hearing development and deafness.

Liu Y, Qi J, Chen X, Tang M, Chu C, Zhu W, Li H, Tian C, Yang G, Zhong C, Zhang Y, Ni G, He SJ, Chai R, Zhong GS. Sci Adv. 2019 Apr 17;5(4):eaav7803. 

  

32. Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.

Yang H, Zhang F, Huang CJ, Liao J, Han Y, Hao PL, Chu Y, Lu X, Li W, Yu H, Kang J. Mol Biol Cell. 2019 Apr 15;30(9):1060-1068.

  

31. Reward Inhibits Paraventricular CRH Neurons to Relieve Stress.

Yuan Y, Wu W, Chen M, Cai F, Fan C, Shen W, Sun WZ, Hu J. Curr Biol. 2019 Apr 1;29(7):1243-1251.e4.  

  

30. Amyloid structure of high-order assembly of Leucine-rich amelogenin revealed by solid-state NMR.

Ma CW, Zhang J, Dong XQ, Lu JX. J Struct Biol. 2019 Apr 1;206(1):29-35.


29.   Development and Application of Base Editors.

Yang B, Yang L, Chen J.CRISPR J. 2019 Apr;2(2):91-104. doi: 10.1089/crispr.2019.0001.


28.   Molecular characteristics of early-stage female germ cells revealed by RNA sequencing of low-input cells and analysis of genome-wide DNA methylation.

  Ma B, Lee TL, Hu B, Li J, Li X, Zhao X, Hou C, Zhang C, He L, Huang XX, Chen X, Li J, Wu J. 

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27. A Chemical Strategy for Amphiphile Replacement in Membrane Protein Research.

Xue D, Wang J, Song X, Wang W, Hu T, Ye L, Liu Y, Zhou Q, Zhou F, Jiang ZX, Liu ZJ, Tao H. Langmuir. 2019 Mar 26;35(12):4319-4327.


26. Switching From Fear to No Fear by Different Neural Ensembles in Mouse Retrosplenial Cortex.

Wang G, Xie H, Wang L, Luo W, Wang Y, Jiang J, Xiao C, Xing F, Guan JS. Cereb Cortex. 2019 Mar 19. pii: bhz050. 


25. Loss of Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division modes

Zhou PJ, Wang X, An N, Wei L, Zhang L, Huang XX, Zhu HH, Fang YX, Gao WQ. Oncogene. 2019 Mar;38(12):2192-2205.


24. Glia in Health and Disease

Ho MS, Verkhratsky A, Duan S, Parpura V. Front Mol Neurosci. 2019 Mar 19;12:63.


23. Cytoophidia respond to nutrient stress in Drosophila

Wu Z, Liu JL. Exp Cell Res. 2019 Mar 15;376(2):159-167.



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22. CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features.

Kartha VK, Sebastiani P, Kern JG, Zhang LY, Varelas X, Monti S. Front Genet. 2019 Feb 19;10:121. 


21. A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells.

Qi J, Liu Y, Chu C, Chen X, Zhu W, Shu Y, He SJ, Chai R, Zhong GS. Cell Discov. 2019 Feb 19;5:12.


20. Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants.

Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao GJ. Dev Cell. 2019 Feb 11;48(3):406-419.e5.


19. mTOR Is Key to T Cell Transdifferentiation.

Yan J, Wang R, Horng T. Cell Metab. 2019 Feb 5;29(2):241-242.


18. Efficient base editing in G/C-rich regions to model androgen insensitivity syndrome.

Li J, Liu Z, Huang S, Wang X, Li G, Xu Y, Yu W, Chen S, Zhang Y, Ma HH, Ke Z, Chen J, Sun Q, Huang XXCell Res. 2019 Feb;29(2):174-176.


17.   Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase.

Hou L , Zhao J, Gao S, Ji T, Song T, Li Y, Wang J, Geng C, Long M, Chen J, Lin H, Cai X, Cang Y. Sci Adv. 2019 Feb 6;5(2):eaau7130. doi: 10.1126/sciadv.aau7130. eCollection 2019 Feb.

 

16.   mTOR-S6K1 pathway mediates cytoophidium assembly.

Sun Z, Liu JL.J Genet Genomics. 2019 Feb;46(2):65-74. doi: 10.1016/j.jgg.2018.11.006. Epub 2019 Jan 31.


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15. Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer.

Liu W , Zhang Z , Zhang ZM , Hao PL, Ding K , Li Z . Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599.


14. Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus.

Luo F, Mu Y, Gao C, Xiao Y, Zhou Q, Yang Y, Ni X,Shen WL, Yang J. J Genet Genomics. 2019 Jan 20;46(1):31-40.


13. Crystal Structure of the Human Cannabinoid Receptor CB2.

Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao SW, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Cell. 2019 Jan 24;176(3):459-467.e13.

  

12. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.

Zhang B, Li J, Yang X, Wu L, Zhang J, Yang Y, Zhao Y, Zhang L, Yang X, Yang X, Cheng X, Liu ZJ, Jiang B, Jiang H, Guddat LW, Yang HT, Rao Z. Cell. 2019 Jan 24;176(3):636-648.e13.


11.   A Tet/Q Hybrid System for Robust and Versatile Control of Transgene Expression in C. elegans.

Mao S, Qi Y, Zhu H, Huang X, Zou Y, Chi T. iScience. 2019 Jan 25;11:224-237. doi: 10.1016/j.isci.2018.12.023. Epub 2018 Dec 27.

 

10.   Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones.

Ai H, Guo Y, Sun D, Liu S, Qi Y, Guo J, Qu Q, Gong Q, Zhao S, Li J, Liu L. Chembiochem. 2019 Jan 18;20(2):221-229. doi: 10.1002/cbic.201800432. Epub 2018 Nov 21.


9.   Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening.

Guo C , Chang Y , Wang X , Zhang C , Hao PL , Ding K , Li Z . Chem Commun (Camb). 2019 Jan 15;55(6):834-837.

 

8.   Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

Wei J, Marisetty A, Schrand B, Gabrusiewicz K, Hashimoto Y, Ott M, Grami Z, Kong LY, Ling X, Caruso H, Zhou S, Wang YA, Fuller GN, Huse J, Gilboa E, Kang N, Huang XX, Verhaak R, Li S, Heimberger AB1. J Clin Invest. 2019 Jan 2;129(1):137-149.


7.   Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.

Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC. Nat Chem Biol. 2019 Jan;15(1):11-17. doi: 10.1038/s41589-018-0160-y. Epub 2018 Dec 3.

 

6.   Principles Governing Catalytic Activity of Self-Assembled Short Peptides.

         Song R, Wu X, Xue B, Yang Y, Huang W, Zeng G, Wang J, Li W, Cao Y, Wang W, Lu JX, Dong H. J Am Chem Soc. 2019 Jan 9;141(1):223-231. doi: 10.1021/jacs.8b08893. Epub 2018 Dec 28.

  

5. Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development.

Yang G, Zhou C, Wang R, Huang S, Wei Y, Yang X, Liu Y, Li J, Lu Z, Ying W, Li XJ, Jing N, Huang XX, Yang H, Qiao Y. Cell Rep. 2019 Jan 8;26(2):302-312.e4.

  

4. Metabolism as a guiding force for immunity

Jung J, Zeng H, Horng T. Nat Cell Biol. 2019 Jan;21(1):85-93.

  

3. Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals

Zhao, Yu; Liu, Changbo; Liu, Zhixiang; Luo, Wenhan; Li, Lizhu; Cai, Xue; Liang, Dong; Su, Yuanzhe; Ding, He; Wang, Qiang; Yin, Lan; Guan, JS; Luo, Minmin; Sheng, Xing. IEEE TRANS.ELECTRON DEVICES.2019 Jan; 66(1):785-792.


2. A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity.

Liu J, Song T, Zhou W, Xing L, Wang S, Ho M, Peng Z, Tai YT, Hideshima T, Anderson KC, Cang Y. Leukemia. 2019 Jan;33(1):171-180.

  

1. AGRP Neurons Project to the Medial Preoptic Area and Modulate Maternal Nest-Building.

Li XY, Han Y, Zhang W, Wang SR, Wei YC, Li SS, Lin JK, Yan JJ, Chen AX, Zhang X, Zhao ZD, Shen W, Xu XH. J Neurosci. 2019 Jan 16;39(3):456-471.

  



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